AIM:To evaluate the effects of basic fibroblast growth factor(bFGF) combined with nature tears II in the treatment of dry eye. ·METHODS:Totally 134 patients with dry eye were randomly divided into experiment group(69 eyes) treated by basic fibroblast growth factor combined with nature tears II and control group(65 eyes)treated by nature tears II with four times every day. The Schimer Ⅰ test(SⅠt),tear film break up time(BUT)were compared with before and one month later in both groups. The results were analysed statistically. ·RESULTS:There were significant difference in SⅠt and BUT one month after treatment in both groups (P<0.01) whereas no difference before the treatment(P>0.05).There were significant difference in SⅠt and BUT in experiment group before and one month later (P<0.01).·CONCLUSION:bFGF combined with nature tears II is an effective method for dry eye.