AIM:To investigate the risk factors of career-related corneal foreign body in Huangpu town of Zhongshan city.METHODS:A total of 123 cases of corneal foreign body were picked out from 446 cases of eye injury during 11 months and 246 subjects of non injury of eye as control were selected from the outpatient,and matched to patients on gender,age and work surrounding with case-control study.Questions were completed face to face by doctors.RESULTS:Temporary employment(OR 9.60,95%CI 5.82-15.90),non-native worker(OR 4.73,95%CI 2.91-7.67),metal-related work(OR 10.50,95%CI 5.79-19.10),below high-school education(OR 4.60,95%CI 2.90-7.29)and not wearing eye protection(OR 7.30,95%CI 4.47-11.90)were risk factors of corneal foreign body.CONCLUSION:In multiple regression model,the risk factors of career-related corneal foreign body include short-term workers,non-native workers,metal-related work and not wearing eye protection.