·AIM:To compare the curative effect after crescent-shaped conjunctiva resection and pharmacotherapy in order to find a safe and effective treatment for conjunctivochalasis.METHODS:A total of 30 patients(60 eyes)with conjunctivochalasis were selected in this prospective randomization control study during April 2009 to March 2010 in Shanghai Ophthalmopathy Prevention and Cure Centre.15 patients(30 eyes)were treated by crescent-shaped conjunctiva resection and 15 patients(30 eyes)by pharmacotherapy.And they underwent system check including objective feeling with OSDI,slit-lamp observation for the residual conjunctiva and the wound healing,operation complications,BUT,measurement of lacrimal river and chloroptic tasting test after 2,4 and 8 weeks of treatment.RESULTS:The OSDI points became lower obviously 4 weeks after crescent-shaped conjunctiva resection,and stable 8 weeks postoperatively.The difference had statistical significance in two groups(t=2.801,P=0.008).The lacrimal river was improved after crescent-shaped conjunctiva resection than that of pharmacotherapy(P<0.01).BUT≥10s in two groups,the difference had no statistical significance 2,4 weeks after treatment(P=0.297),however there was statistical significance 8 weeks after treatment(χ2=5.455,P=0.020).After 8 weeks the chloroptic tasting test of 14 eyes(46.6%)was positive in crescent-shaped conjunctiva resection,and 6 eyes were(20.0%)positive in drug therapy group(χ2=4.800,P=0.028).Residual score of postoperative conjunctiva was 10 after two weeks,7 for 4 weeks and 6 for 8 weeks.Operation complications score was 6 after 2 weeks,12 for 4 weeks and 8 for 8 weeks.CONCLUSION:Crescent-shaped conjunctiva resection for treating conjunctivochalasis is safe and effective;however ophthalmic solutions can only improve the symptoms.