·AIM:To observe and discuss the therapeutic efficacy of combining therapy for amblyopia in adolescents and older children.METHODS:A total of 90 cases(148 eyes)were randomly selected from the patients,which were treated with occlusion therapy,red light glitter,photogene,haidinger,meticulous homework,laser therapy and mind-cure in our hospital from August 2005 to January 2009.The 8-10 age group was of 114 eyes,11-13 age group of 24 eyes,and 14-16 age group of 10 eyes.The course of treatment was 30-750 days,the mean was 163 days.The data were analyzed retrospectively.RESULTS:Vision had raised 2 lines or more after the treatment,the effective rate was 93.3%.98 eyes’ corrected visual acuity arrived at 0.9,The recovery rate was 66.2%,the therapeutic efficacy of 8-10 age group was significantly different with that of 11-13 age group and 14-16 age group.CONCLUSION:The therapeutic efficacy of combining therapy for amblyopia in hobbledehoy and older children is affirmed,especially on establishing good visual function after treatment for central fixation amblyopia with ametropia.