Retinal pigment degeneration is a common genetic disorder that generally involves both eyes and ultimately leads to blindness.At present there is no clinically effective treatments.In recent years,considerable progress has been made in retinal pigment degeneration of gene therapy,growth factor treatment,retina transplantation and artificial retina,etc.In addition,classic drug therapy and traditional medical treatment also have new exploration.Now the development and research status in treatment of retinal pigment degenerative disease are reviewed in this paper.