AIM:To observe the effect of nasolacrimal duct laser probing surgery and artificial nasolacrimal stent retrograde implantation in treatment of nasolacrimal duct obstraction.METHODS:A total of 54 patients 69 eyes with nasolacrimal duct obstruction were screened,and those who met the surgical indication,suffering severe epiphora with or without pus overflow were treated with laser nasolacrimal duct probing combined retrograde stent implant and followed up for 3-12 months.RESULTS:All patients were successfully implanted artificial nasolacrimal duct stent,mean operative time was 15.48 minutes.Epiphora symptoms were improved immediately after surgery,lacrimal duct were patent.The time of observing for 3,6 and 12 months,cure rates were 100% and 97% and 91%.CONCLUSION:Laser probing of nasolacrimal duct combined with nasolacrimal duct stent retrograde implantation is a simple,safe and effective treatment method for nasolacrimal duct obstruction,without skin scars,changing of the physical anatomy and so on.