AIM:To observe the effect of mecobalamin on neurological recovery in the treatment of macular edema.METHODS:Three hundred and twelve cases 487 eyes of macular edema caused by retinal vascular diseases were enrolled and divided into two groups.The control group was treated with various methods to relieve the macular edema only,while the trial group was treated with additional neuroprotective medicine,mecobalamin,at least for one month.RESULTS:A better visual prognosis was gained in the trial group.CONCLUSION:The neuroprotective therapy is profitable in the treatment of macular edema in addition to the routine edema-relief-medicine.