·AIM:To observe the protective effect of fuguang pellet on optic nerve through the research of expression of apoptosis-related genes(Bcl-2,Bax)in the rabbits after crushing the optic nerve with microforceps.·METHODS:By the method of crushing rabbit optic nerve,the models of traumatic optic neuropathy(TON)were set up.By determination of the expression of apoptosis-related genes(Bcl-2,Bax)in the rabbits’ optic nerve,the influence of the fuguang pellet on injured optic nerve was observed.·RESULTS:After the rabbits’ optic nerve was crushed,there were significant differences in the expression of apoptosis-related genes(Bcl-2,Bax)between model group and the group of the fuguang pellet(P<0.05).There were no significant differences between the group of high-dosage group and low-dosage group of the fuguang pellet.·CONCLUSION:Fuguang pellet can decrease damages of optic nerve by increasing Bcl-2 gene expression and restraining Bax gene expression in this experiment.·