·AIM:To investigate the effect of soft corneal contact lens on central corneal thickness.·METHODS:Central corneal thickness was detected with ultrasonic corneal pachymetry,myopic patients who wore soft contact lens and who did not wear soft contact lens of 100 cases 200 eyes were randomly selected in our hospital for statistical analysis.Then according to the wearing time <1 year,1-3,3-5,5-7,≥ 7 years they were grouped,60 patients(120 eyes)were randomly selected from each group to do statistical analysis.·RESULTS:Corneal thickness of those who wore soft contact lens being compared with those who did not wear soft contact lens,the difference was statistically significant(P<0.05).For comparison of corneal thickness with wearing time <1 year,1-3,3-5,5-7,≥ 7 years,the difference was statistically significant(P<0.05).·CONCLUSION:The average central corneal thickness of those who wear soft contact lens is thinner than those who do not wear contact lens,the longer they wear soft contact lens,the thinner their central corneal thickness is.·