·AIM:To investigate,evaluate and analyze clinical effect of vitrectomy for endogenous Klebsiella endophthalmitis.·METHODS:A total of 11 patients(12 eyes)with endogenous Klebsiella endophthalmitis underwent vitrectomy.According to the condition of retina,they were accompanied with membrane peeling and silicone oil tamponade during vitrectomy.·RESULTS:Postoperatively,vitreous cavities of 12 eyes were all clear,visual acuity was better than before.3 eyes(25%)achieved final visual of 0.1-0.3.The follow-up time was 3 months,and only 2 eyes developed lens opacity.·CONCLUSION:Vitrectomy is an effective method for endogenous Klebsiella endophthalmitis.·