·AIM:To investigate the reasons and enlightenment for re-operation of intraocular lens(IOL)off after vitrectomy and double-loop suture.·METHODS:From June 2005 to September 2007,9 patients with IOL off after vitrectomy and loop suture were reoperated with loop suture of IOL under local anesthesia.Non-degradable sutures were used,without affecting the optical zone to retain the original IOL as much as possible,the loop was sutured again symmetrically and no tension as far as possible.·RESULTS:The results were followed up for 3-5 years.Compared with preoperative,visual acuity was significantly improved and IOL was stable.·CONCLUSION:There are several reasons for IOL off after loop suture:external force,IOL material,loop suture degradation,thread tension.By avoiding these factors as much as possible,a small invasive surgery can be done again to obtain better visual acuity and stabilize the therapeutic effect.·