AIM:To compare clinical results between epipolis laser in situ keratomileusis(Epi-LASIK) and epithelial removal Epi-LASIK for the treatment of low to moderate myopia.METHODS:This retrospective analysis comprised 38 eyes treated by Epi-LASIK(A group) and 34 eyes treated by epithelial removal Epi-LASIK(B group) on low to moderate myopia with a follow-up of 2 years. Recover situation of the early stage after operation,vision, haze,diopter of the middle,later stage were observed.RESULTS: All eyes were operated successfully. There was significant difference in the clinical symptom. The number of cornea transparent eyes in the second day of postopertaion of A group was more than B group. The difference had statistical signifcance. There was significant difference in the vision of 7 days,1 month of postoperation, that of A group was better than B group,and no significant difference in the 3 months,12 months,24 months of postoperation. There was significant difference in the diopter of 1 month postoperation of A group to B group,and no significant difference in the 3 months,12 months,24 months of postoperation. There was no significant difference in the haze of A group to B group.CONCLUSION: Both Epi-LASIK and epithelial removal Epi-LASIK have safety, effectiveness,stability and predictability.Epithelial removal Epi-LASIK is better in the valid vision and to alleviate discomfort in the early stage of postoperation than Epi-LASIK.