Herpes simplex keratitis (HSK) is a delayed allergy caused by viral antigens and T lymphocytes mediated.The detailed mechanism how T lymphocytes mediated HSK immune response is still unknown, but from the present research it can be summarized that the promote inflammatory factor of T lymphocyte cell factors such as IL-2, IL-10, IL-17,IFN-γ play an important role in the recurrence processing of herpes simplex keratitis. This paper will be briefly reviewed the progress about the research of T-lymphocytes and its cytokines with herpes simplex keratitis.