AIM:To study the variations of the intraocular pressure (IOP) and the ocular pulse amplitude (OPA) in the acute angle-closure glaucoma after laser peripheraliridectomy. METHODS: Totally 19 patients (19 eyes) were taken into the study. They were measured by the dynamic contour tonometry (DCT) before and 30 minutes after instillating 10g/L pilocarpine, 30 minutes and 1 week after the laser peripheraliridectomy. RESULTS: The mean IOP was 17.61±4.23mmHg, 17.35±3.52mmHg before and 30 minutes and 1 week after the 10g/L pilocarpine instillation, and 19.33±4.24mmHg, 16.08±2.13mmHg 30 minutes and 1 week after the laser peripher- aliridectomy. The mean OPA was 2.69±0.89mmHg, 2.72±0.93mmHg,3.03±0.89mmHg,2.51±0.69mmHg before and 30minuts after the pilocarpine instillation, 30 minutes and 1 week after the laser peripheraliridectomy.The IOP and OPA significantly increased 30 minutes after the laser peripheraliridectomy(P<0.05).The OPA was positive correlated with the IOP. CONCLUSION: The IOP and OPA will significantly increase 30minuts after the laser peripheraliridectomy in acute angle-closure glaucoma. The OPA is positive correlated with the IOP.