AIM:To analyze curative effect of grid photo-coagulation in treatment of macular vesicular edema caused by central retinal vein occlusion.METHODS:One hundred thirty-seven patients (137 eyes) with macular vesicular edema caused by central retinal vein occlusion were detected with visual acuity,optical coherence tomography(OCT) and fundus fluorescein angiography(FFA) 1 week, 1 month, 3 months after grid photo-coagulation. RESULTS:Totally 119 eyes(86.9%) showed visual improvement and 18 eyes(13.1%)showed visual stability 1 month after treatment; 124 eyes(90.5%) showed visual improvement and 13 eyes(9.5%)showed visual stability 3 months after treatment. The visual acuity improved significantly 1 month and 3 months after treatment. CONCLUSION: The curative effect of grid photo-coagulation in treatment of macular vesicular edema caused by central retinal vein occlusion is affirmative. It is necessary that there should be sufficient effective photo-coagulation spot and correct photo-coagulation modality based on fundus condition in treatment.