AIM:To analyze the therapeutic effectiveness of the fibrin sealant with limbal stem cell transplantation in the treatment of recurrent pterygium.METHODS: Totally 88 eyes with recurrent pterygium were randomly divided into two groups: observer group of limbal stem cell transplantation with fibrin sealant and control group of string with limbal stem cell transplantation in the treatment of recurrent pterygium.RESULTS:The recurrence rate was 2.2% in observer group and 14.3% in control group, respectively(P<0.05). Postoperatively, the foreign bodies sensation and the rate of transplant edema in observer group were less than that in control group.CONCLUSION:Fibrin sealant with limbal stem cell transplantation for treating recurrent pterygium has the advantage of slight trauma, mild pain, short operative time,early recovery.It is a more effective and satisfactory surgery way. 