AIM:To analyze the efficacy of using compound anisodine in the treatment of brain injury induced oculomotor paralysis.METHODS: Totally 42 cases of patients diagnosised with brain injury induced oculomotor paralysis,were analysed retrospectively. All patients were injected with compound anisodine injection subcutaneously around superficial temporal artery, 2mL per time and one time per day, totally 14 days per course of the treatment. At the same time, they all got high pressure oxygen therapy one time per day, altogether 10 days per course of treatment.RESULTS: Complete remission meant that disappearance of diplopia and ptosis, recovery to normal bulbus oculi action, correct position of eyes and normal size of pupil. Improvement meant that improvement of diplopia, ptosis and bulbus oculi action disorder, incorrect position of eyes, and partial recovery of pupil. Inefficacy meant that no manifest improvement of over-mentioned symptoms.Totally, 12 cases got complete remission, improvement in 29 cases and inefficacy in one.CONCLUSION:Compound anisodine injection subcutaneously combining with high pressure oxygen therapy is an effective and reliable treatment for patients with brain injury induced oculomotor paralysis.