AIM:To explore the clinical application of complex anisodine Ⅱ combined with ixeris sonchifolia in treating anterior ischemic optic neuropathy(AION)(non-temporal arteritis type).METHODS:Thirty-eight patients(38 eyes) who were clinically diagnosed as AION(non-temporal arteritis type) were randomized into two groups.Group A used routine treatment,including hyperbaric oxygen;orally taken acetazolamide,vitamin B1,vitamin B12,compound salvia miltiorrhiza tablet;intravenous taken salvia miltiorrhiza injection 20mL.Group B used the routine treatment plus complex anisodine II subcutaneous injection beside the affected side arteriae temporalis superficialis combined with intravenous ixeris sonchifoila 20mL.The period of treatment was 10 days for the both groups.Visual acuity and fundus oculi were examined every day.Preoperative and postoperative visual field and FFA were compared.RESULTS:Compared with group A,group B had quick and better improvement of visual acuity(P<0.05).And the group B had better results of visual field and FFA test,when compared with group A(P<0.05).CONCLUSION:The use of complex anisodine II combined with ixeris sonchifolia in treating AION(non-temporal arteritis type) is safe and efficient.