AIM:To investigate the effects of huwangmingmusan on retinal endothelial cells of Wistar rats infected diabetic retinopathy with streptozotocin(STZ).METHODS:The Wistar rats were divided into three groups:model,Chinese medicine,and western medicine.And also,a healthy group was prepared for comparison.After successive administration for 45 days,the rats eyes were used to prepare retinal vascular digest preparations and stained with PAS routinely.The rats endothelial cells were observed.RESULTS:No proliferation and apoptosis of rat retinal vascular endothelial cells was in normal group.There were no significant differences between Chinese medicine group and the normal group in the number of endothelial cells and apoptosis(P>0.05);but there were significant differences comparing with model group and western medicine group(P<0.01,P<0.05).CONCLUSION:Huwangmingmusan can inhibit the proliferation and apoptosis of retinal capillary endothelial cells of Wistar rats infected diabetic retinopathy with STZ and have protective effect on the endothelial cells.