AIM:To compare the reducing pain-degree when inserting needle between patients accepting modified temporal-subcutaneous injection and the traditional way,and explore the clinical feasibility of the modified temporal-subcutaneous injection.METHODS:To use the patients who accepted the compound anisodine temporal-subcutaneous injection as subject investigated,some patients accepted the way of the vertical needle(modified temporal-subcutaneous injection),the other accepted the traditional way(normal temporal-subcutaneous injection),and the pain-degree of two groups were compared.The assigned persons observed the patients’ response to pain with the Wong-Baker facial scale,collected the data of the patients’ response to pain,then made statistical analysis of the data.RESULTS:The pain-degree of modified temporal-subcutaneous injection was significantly lower than that of the traditional way.CONCLUSION:The modified temporal-subcutaneous injection can significantly reduce pain-degree when patients accept temporal-subcutaneous injection,thereby improve the compliance when patients accept the treatment of temporal-subcutaneous injection.