AIM:To evaluate the effect of deep lamellar keratoplasty for the treatment of keratoconus.METHODS:Deep lamellar keratoplasty was applied for treatment of 132 cases (140 eyes) with keratoconus.The effectiveness of operation was clinically observed and evaluated.Postoperative follow-up were 6- 48 months.RESULTS:The postoperative corrected vision was 0.2- 0.4 in 13 cases (14 eyes),>0.4- 0.8 in 92 cases (96 eyes),>0.8 in 27 cases (30 eyes).Rejection occurred in 5 eyes,clear graft in 131 cases (139 eyes),semitransparent in 1 cases (1 eye),8 eyes appeared Descemet’s layer folds.CONCLUSION:Deep lamellar keratoplasty with fewer complications,can reduce the incidence of endothelial rejection.Postoperative visual acuity is good,and there is less demanding on the donor material,etc.It provides a safe and effective choice for the treatment of keratoconus.