AIM:To observe the clinical efficacy of different types of fundus disease with vitrectomy.METHODS:Clinical data of different types of fundus disease in 91 cases(96 eyes) with vitrectomy were analyzed retrospectively,in which fundus disease combined with proliferative diabetic retinopathy were 54 cases (59 eyes),with high intraocular pressure were 21 cases;purely high intraocular pressure retinopathy,8 cases (8 eyes);purely retinal detachment,17 cases (17 eyes);other reasons such as trauma,proliferative vitreoretinopathy,12 cases(12 eyes),and the reasons for poor visual recovery after surgery were summed up.RESULTS:All patients were followed up for 1 month to 6 months,the postoperative vision of 71 eyes in 96 eyes which was compared with preoperative vision improved to varying degrees,accounting for 74% of the total number of eyes (71/96),including the postoperative vision of 18 eyes improved from light perception,hand movement and finger counting to over 0.1,accounting for 19% of the total number of eyes (18/96);the postoperative vision of 9 eyes increased to over 0.02 but below 0.1,accounting for 9% of the total number of eyes (9/96);the postoperative vision was not improved in 20 eyes,accounting for 21% of the total number of eyes (20/96);the postoperative vision decreased in 5 eyes,accounting for 5% of the total number of eyes (5/96).CONCLUSION:Vitrectomy which treats different types of fundus disease is obviously effective and safe,which can improve visual function in most eyes and has fewer complications.