AIM:To evaluate the impact of ultrasonic atomization of methylcobalamin on corneal nerve recovery after LASIK.METHODS:Seventy-two patients in our hospital underwent LASIK,refraction degree -1.50-- 4.50D were randomly divided into A,B,C three groups,each group 24 cases.After LASIK surgery,all patients were treated as following:group A (control group) without anti-dry eye treatment;group B using artificial tears after surgery;group C(ultrasonic atomization methylcobalamin group) using ultrasonic spray methylcobalamin treatment after surgery.We observed tear film break up time (BUT),tear secretion amount and corneal anterior stromal layer of nerve fiber density in three groups preoperative and postoperative 1 week,1 month and 3 months.RESULTS:Compared with the group A,BUT in group B after 1 month significantly increased,and it significantly increased in group C postoperative 1 week,1 month and 3 months(P<0.05).Compared with group A,tear secretion amount in group B and C during different periods increased significantly(P<0.05).Compared with group B,tear secretion amount in group C after 1 month and 3 months increased significantly(P<0.05).Nerve fibers in the central district area of newborn increased significantly in group C compared with group A and B after LASIK corneal surgery(P<0.05).CONCLUSION:Ultrasonic atomization of methylcobalamin on patients after LASIK corneal surgery can reduce the occurrence of dry eye and repair the damaged corneal sensory nerves.