AIM:To observe the effects of sevoflurane inhalation anesthesia on strabismus operation in children.METHODS:Sixty children of ASA (American society of anaesthetist)grade Ⅰ-Ⅱ were randomly divided into two groups,each group had 30 cases.Group A was treated with sevoflurane,midazolam and vecuronium for induction,sevoflurane for maintenance.Group B was treated with propofol-remifentanil plus ketamine,midazolam and vecuronium for induction,propofol-remifentanil for maintenance.The haemodynamics of pre-intubation,intubation,operation and recovery period were monitored.The time of respiratory recovery,extubation and awareness recovery were recorded.The anaesthetic complication were also recorded.RESULTS:The changes of HR and BP in Group A during intubation increased more than those in Group B,the variances were statistically different between two groups (P <0.05).The variances of haemodynamics were statistically different between Group A and Group B (P<0.05).The eye-heart reflex in Group A was less than those in Group B and the variances were statistically different between two groups (P<0.01).The postoperative agitation in Group A were more than those in Group B and the variances were statistically different (P<0.01).CONCLUSION:The haemodynamics with sevoflurane inhalation anesthesia on strabismus operation in children are stable,and it can significantly reduce the eye-heart reflex.The recovery is more rapidly,but the postoperative agitation is higher.