AIM:To explore the nursing care of intravitreal Lucentis injection to treat the patients withage-related macular degeneration(AMD).METHODS:Thirty patients(30 eyes) were diagnosed as AMD.They would be treated by intravitreal Lucentis injection.The preoperative psychological nursing was emphasized.Complications,especially intraocular pressure were observed.RESULTS:Twenty-one eyes were improved in visual acuity in all 30 eyes.The intraocular pressure(20.1-24.6mmHg) in 4 eyes were higher than preoperative,which was normal 24 hours later.No complications were observed in the follow-up.CONCLUSION:It is very important to enhance the peri-injection,mid-injection and post-injection nursing for assuring the treatment efficacy.