AIM:To analyse the characteristics of retinal lesions in myopic patients scheduled for laser in situ keratomileusis(LASIK),then to assess the efficacy and safety of prophylactic laser coagulation for retinal lesions in these myopic eyes·METHODS:Retrorespective clinical research.LASIK were performed in 1100 continuous patients(2190 eyes).Before operation,the fundus was examined with direct and indirect ophthalmoscope and three mirror contact lens.The laser photocoagulation was performed in order to strengthen the retina with severe peripheral degeneration·RESULTS:Peripheral fundus abnormalities and holes both increased while refraction diopter increased,and there were statistically significant differences among groups(P<0.05).And the abnormalities were usually in the temporal fundus.A total of 2190 eyes were examined.Among them,132 eyes(6.07%) were found to have peripheral retinal degeneration:64 eyes(48.48%) had lattice degeneration,37 eyes(28.03%) had cystoid degeneration,54 eyes(40.91%) had snail track degeneration,34 eyes(25.76%) had white non-pressure change,12 eyes(9.09%) had cobblestone degeneration,14 eyes(10.61%) had retinal dry holes,4 eyes(3.03%) had hole and localized shallow detachment.The pathological changes in 43 cases(78 eyes) were treated effectively by laser photocoagulation for more than three weeks,and eventually the holes were firmly closed and the lattice degeneration,the cystoid degeneration were photocoagulated reliably.No new holes and retinal detachment occurred·CONCLUSION: It’s necessary to examine the fundus of the two eyes with the three-mirror contact lens before LASIK.To prevent retinal detachment effectively,laser photocoagulation should be performed in time on the peripheral retinal degeneration of myopia.