AIM:To study the treatment and efficacy of comprehensive therapy for blepharospasm. METHODS:Several methods were as follows: therapy for primary external ophthalmopathies, psychological therapy, acupuncture therapy, systemic and local drug therapy.The above comprehensive therapies were used to treat blepharospasm. RESULTS:About 77.4 percent of the patients with blepharospasm symptoms disappeared after 6 times acupuncture therapy. 96.8 percent of the patients symptoms disappeared after 12 times acupuncture therapy.3.2 percent of the patients symptom did not disappear after acupuncture therapy. CONCLUSION:It is an effective and safe treatment of blepharospasm with comprehensive therapy.