AIM:To assess the clinical outcomes of implantation of a lens consisting of a biocompatible collagen copolymer (Visian implantable Collamer lens \[ICL\]; STAAR Surgical, Nidau, Switzerland) for moderate to high myopia. METHODS:Totally 24 eyes of 15 patients with myopic refractive errors of -3.50 to -15.50 diopters (D) who underwent ICL implantation and routine postoperative examinations were evaluated. Before and 1day,1 month, 3, 6 and 12 months after surgery, the safety, efficacy, predictability, stability, and adverse events of the surgery were assessed. RESULTS:The uncorrected visual acuity was 0.90±0.29(0.5-1.5) after surgery, higher than the mean preoperative best-corrected visual acuity 0.84±0.24(0.4-1.2) with non-significance (P>0.05). The average values for spherical refractions were -0.20±0.68（1.00- -1.25）DS after surgery, lower than that of preoperative -10.19±3.37(-3.50--15.50)DS with remarkable significance (P<0.05). The average values for cylindrical refractions were -0.41±0.58DC after surgery, lower than that of preoperative -1.98±1.62DC with remarkable significance (P<0.05). The average anterior chamber depth were 225±0.32mm after surgery, lower than that of preoperative 3.08±0.21mm with remarkable significance (P<0.05).There was not significant difference between preoperative and postoperative intraocular pressure. The surgery was without serious complications. CONCLUSION: Implantation of ICL is safe and effective and provides predictable and stable refractive results in the treatment of moderate to high myopia during one-year observation, suggesting its viability as a surgical option for the treatment of such eyes.