AIM:To explore the methods and efficacy of hormone therapy of acute anterior uveitis, to reduce the recurrence rate. METHODS:Totally 142 cases of acute anterior uveitis were given conventional topical subconjunctival injection of dexamethasone 2-3mg, 1 time/day,at the same time local allusions of TobraDex and 1g/L diclofenac sodium eye drops. Individual cases could not control the disease by topical steroid therapy, then resorted to high-dose oral prednisone 80-100mg, 10-20mg daily reduction, withdrawal afer 3-5 days, generally not more than 1 week, and continued topical steroid therapy. RESULTS: All patients healed within 30 days, without any systemic complications, without recurrence within six months, the relapse rate was 14.8% ( 21 cases) within a year. CONCLUSION:The majority of acute anterior uveitis need not systemic hormone therapy, at the same time prolonged courses of treatment may be effective to reduce the recurrence rate.