AIM:To investigate clinical feature,pathogenesis and treatment methods of herpes simplex keratitis(HSK)with glaucoma． METHODS:Diagnostic standard was intraocular pressure ≥24mmHg.Standard clinical cure was corneal lesions still and intraocular pressure ≤21mmHg after stopping ocular hypotensive drugs for one week．30 cases with secondary glaucoma were given combined antiviral, anti-inflammatory and intraocular pressure reduction treatment. RESULTS:Clinical cure of 30 cases were obtained by antiviral，anti-inflammatary and ocular hypotensive drugs． CONCLUSION:The inflammation and intraocular pressure could be controlled through active antiviral，anti-inflammatary and ocular hypotensive drugs treatment．Individualized survey of intraocular pressure is necessary for HSK secondary glaucoma.