AIM:To analyse ocular melanomas clinical and pathological specifics for earlier diagnosis and treatment. METHODS:Twenty-four cases with ocular melanoma were retrospectively collected during July 2002 to July 2011 and patients clinical and pathological history were reviewed. All samples had routine paraffin section, HE dying and some difficult diagnosed samples plus S-100 protein and HMB-45 s-p immunohistochemical method. Excel was used for establishment of a database and software SPSS 17.0 applied for statistical analysis. RESULTS:All 24 cases were ocellus, with 13 males and 11 females; 14 left eyes and 10 right eyes; 3 cases of eyelid malignant melanoma, 6 cases of primary malignant melanoma of conjunctiva and 15 cases of uveal melanoma respectively. CONCLUSION:Diversity of melanoma histopathology exists. Most cases can be confirmed by routine pathological method. Immunity histochemistry is of high value for diagnosis or differential diagnosis of melanoma.