AIM:To observe differences of orthokeratologys functions in controlling or slowing down the development of myopia for teenagers myopia with different diopter. METHODS: After correcting those myopia teenagers with spherical equivalent refraction between -1.00--5.00 D and astigmatism no more than -1.50 D by OK contact lens,169 cases (316 eyes) of myopes were divided into four groups according to the degree of refraction: Ⅰ(dioptre :-1.00--2.00DS), Ⅱ(dioptre : -2.25--3.00DS), Ⅲ(dioptre : -3.25--4.00DS), Ⅳ(dioptre : -4.25--5.00DS) myopic groups. They were followed up at 6, 12, 24 months after wearing glasses. Then results of groups with uncorrected visual acuity over 1.0 and 0.8 were analyzed statistically. RESULTS: Six months after wearing glasses, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity over 1.0 were 100%, 96.2%, 93.6% and 88.6% respectively.12 months after wearing glasses, the ratios of groupⅠ,Ⅱ, Ⅲ and Ⅳ with uncorrected visual acuity over 1.0 were 87.3%, 84.8%, 77.2% and 70.9% respectively. Accordingly, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity between 0.8 and 1.0 were 12.7%, 15.2%, 22.8% and 29.1% respectively. 24 months after wearing glasses, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity over 1.0 were 595%,54.4%,53.2% and 45.6% respectively. Accordingly, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity between 0.8 and 1.0 were 152%, 19.0%, 13.9% and 10.1% respectively. CONCLUSION: The results suggest negative correlation between the degree of myopia and the effect of orthokeratology in controlling or slowing down the development of teenagers myopia. Orthokeratology is more effective in group with medium myopia and low myopia than that in group with high myopia. Therefore, its more appropriate for myopia teenagers with early medium myopia and low myopia using orthokeratology. It has advantages such as fast-acting, non-invasive and reversible and can be used in controlling or slowing down the development of teenagers myopia.