To evaluate clinical effect of Hexuemingmu tablet combined with photocoagulation treatment on retinal periphlebitis. METHODS：Thirty patients (42 eyes) diagnosed as early retinal periphlebitis were divided into two groups randomly. The control group were treated by laser photocoagulation and treatment group were treated by laser photocoagulation combined with oral hexuemingmu tablet for 3 months. In two groups, the patients with causes of disease found out were given symptomatic treatment and the follow-up was from 1 month to 3 years. RESULTS：The effective rate in control group was 80 percent, and that in treatment group was 95.5 percent.Two groups were different from each other in statistics (P＜0.05). CONCLUSION：Laser photocoagulation combined with oral hexuemingmu tablet works well in retinal periphlebitis treatment.