AIM: To research tissue and ultrastructure in retinal pigment epithelium（RPE） of apolipoprotein E-deficient(ApoE-/-) mice effected by dyslipidemia in using jianpiquyu method,and to explore the effects on the VEGF/VEGFR2 pathway. METHODS: Thirty-six 2-month-old ApoE-/-mice were randomly divided into three groups:the group of normal chow(group A);the group of high fat chow(group B)，the group of treatment(group C),twelve mice in each group.Animals were killed after five months feeding and animal bodymass,blood lipid and hemorheology levels were detected．RPE was observed by light microscopy,transmission electron microscopy and immunohistochemistry． And the VEGF were analysed by Western blot. RESULTS: The animal bodymass,lipid and hemorheology levels in group B were significantly higher than those of group A and group C(P＜0.05).The thickness of RPE in group A was statistically higher than that of group B and group C(P＜0.05)，but there was not statistically signigicant difference between group B and group C（P>0.05）.VEGF and VEGFR2 dyeing area and intergral optical density in group B were higher than those of group A and group C(P＜0.05).Protein expression in retina in group B was higher than that of group A and group C(P＜0.05). CONCLUSION: It plays a positive role in ameliorating biochemical indicators such as lipid and hemorheology levels in dyslipidemia ApoE-/-mice by using jianpiquyu method.It also plays a regulatory function in the VEGF/VEGFR2 pathway in this age-related macular degeneration (AMD) animal model.