GlycoproteinB,D（gB， gD） are essential components for infection by herpes simplex virus-1 (HSV-1)，possess important epitope, participate in viral transmembrane process, mediate virus spreading between the cells, and play an important role in the process of host immune and viral infection.The study of their molecular and functional properties has important significance for research of herpes simplex keratitis(HSK) mechanism of action and preventation. In recent years, the research in HSVgB, HSVgD has certain progress, already developed vaccine specific to HSVgB, HSVgD epitope. Here,we reviewed the research progress in HSK related gB, gD and vaccine.