AIM:To investigate the outcome of combining grafting of hard palate mucosa and orbicularis musculocutaneous flap in the reconstruction of full-thickness eyelid defects caused by eyelid malignant tumor． METHODS:For all 10 cases (10 eyes) with medium to severe full-thickness eyelid defects larger than or equal to the 1/2 full length of eyelid,oral hard palate mucosa grafting plates were used to substitute tarsal plates and conjunctivas and reconstruct posterior layer eyelids；orbicularis musculocutaneous flaps were transferred to cover the hard palate mucosa and substitute the defected eyelid skin and muscle layer and reconstruct anterior layer eyelids． RESULTS: All cases were followed up for more than 6 to 12 months．Appearance of eyelids and functional improvements were satisfactory．The hard palate mucosa grafting plates and their transfer flaps survived without untoward effects of contraction, dislocation, infection or necrosis． CONCLUSION:Combining grafting of hard palate mucosa and orbicularis musculocutaneous flap can repair full-thickness eyelid defects as a one-stage operation with definite and good outcome．