AIM: To evaluate the vision related quality of life (VRQOL) and anxiety and depression symptoms and investigate its changes in primary angle-closure glaucoma (PACG) by trabeculectomy interventions. METHODS: The present study included 42 PACG patients.A healthy control group(n=42)sociodemografically matched to the group was established. The VRQOL and anxiety and depression symptoms were evaluated and analyzed on the pre-operative and post-operative month 1 by using two instruments. Instruments applied included the NEI-VFQ-25 and Hospital Anxiety and Depression Scale (HADS). RESULTS: The incidence of anxiety, depression, anxiety combined depression in comitant constant esotropia patients was 23.8%, 23.8%, 16.7%, respectively. Compared with control subjects, PACG patients showed significantly impaired disease-specific VRQOL in 10 out of 12 subscales, including ‘General Health’, ‘General Vision’ , ‘Ophthalmological pain’, ‘Social Functioning’, ‘Distance vision’, ‘Mental Problems’ , ‘Peripheral Vision’, ‘Near vision’ , ‘ Social role’ and ‘Dependency’ (P<0.05)．Compared with pre-operative values, significant improvements were noted after surgery in NEI-VFQ summary score, anxiety and depression scores (P<0.05). The VRQOL of PACG patients improved at 1 month after second surgery compared with those of pre- surgery：MD=41.6(General Health), 34.5(Ophthalmological pain), 32.6(Society Functioning), 21.2(Mental Problems), 24.8 (Social Activities), 21.8(Dependency) \[F=10.4(General Health), 6.4 (Ophthalmological pain), 10.6 (Society Functioning), 8.3 (Mental Problems), 7.3 (Social Activities), 6.9(Dependency)；P<0.05\]. CONCLUSION: PACG patients were affected in mentation and VRQOL while surgery interventions can improve VRQOL, anxiety and depression in strabismus patients.