AIM:To compare the effects of two fixedesotropia operation method.METHODS:Retrospectively analyzed the operation courses of 26 cases(45 eyes) with fixed esotropia in the last 11 years. During January 2000 to December 2006, surgeries were done for 17 eyes to cut off tendon of medial rectus and shorten lateral rectus for an excessive amount (Surgery I). During January 2007 to December 2010, surgeries were taken for 28 eyes to cut off tendon of medial rectus, overlap lateral rectus and fix it to orbital periosteum on the side of temporal bone (Surgery II). RESULTS:Among the 17 eyes on which Surgery I was performed, it was found that 4 eyes turned inward for more than 15 degrees 1 day after the surgery. Then surgeries were taken immediately to fix lateral rectus on orbital periosteum so that the eyes could be over corrected for 5-10 degrees. During follow-up about 1 year after surgery, the eyes were over corrected for about 5-10 degrees. During follow-up of the other 13 eyes in 6-18 months after surgery, esotropia of 10-30 degree occurred on 7 eyes. Surgeries were practiced in all of them to fix lateral rectus on orbital periosteum and over correct the eyes for 5-10 degrees. During their visits in 1 year after surgery, the eyes were over corrected for about 5 degrees. Of the 28 eyes on which Surgery II were performed, it was found that all of the eyes were over corrected, and were similar to the surgical designs. During their visits in 1-2 years after surgery, the eyes were over corrected for about 5 degrees. Patients of 2 cases visited us for 3-4 years, and their eyes were slightly over corrected for within 5 degrees.CONCLUSION:Regular surgical treatment for fixed esotropia could not achieve better effect, and the surgical effect will regress in time. The surgery to cut off tendon of medial rectus and shorten lateral rectus for an excessive amount has achieved better effect. It is safer and less difficult. The rate of success is high. And, the rate of regression is low according to statistics of patient visits after the surgery for a long time. It is the one that should be applied in wider scope. 