AIM:To investigate the use of argon green laser photocoagulation combined with traditional Chinese medicine treatment of diabetic macular edema (diabetic macular edema, DME) efficacy.METHODS:Totally 68 cases (132 eyes) with diabetic edema during August 2010 to June 2011 were colected. All the cases were randomly divided into two groups:treatment group of 35 cases (68 eyes), control group of 33 cases (64 eyes). Treatment group used argon green laser combined with traditional Chinese medicine for the treatment of DEM, control group was treated with argon green laser only. After 6 months, visual acuity, fundus fluorescein angiography(FFA), optic coherence tomography(OCT) were exmanied and statistical analysis were performed.RESULTS:Six months after treatment, visual acuity of treatment group improved or stabilized in 62 eyes (91.2%), decreased in 6 eyes (8.8%). Visual acuity of control group improved or stabilized in 49 eyes (76.6%), decreased in 15 eyes (23.4%). There was statistical significance between two groups (P＜0.05). FFA showed that macular edema partial or complete regressed in 63 eyes (92.7%), did not disappear in 5 eyes (7.3%) in treatment group. Macular edema partial or complete regressed in 50 eyes (78.1%),did not disappear in 14 eyes（21.9%）in control group. There was statistical significance between two groups (P＜0.05). OCT showed that macular edema in treatment groupalleviated or stabilized in 61 eyes (89.8%), unchanged or aggravated in 7 eyes (10.2%). Macular edema in control group alleviated or stabilized in 44 eyes (68.8%), unchanged or increased in 20 eyes (31.2%). Comparison of the two groups was statistically significant (P＜0.05 ).CONCLUSION:Argon green laser photocoagulation combined with traditional Chinese medicine for treatment of DEM is safe and effective.