The ultrasound microbubble contrast agent to carry the drug and gene targeting therapy system is a new hot research field. In recent years,it is widely used in targeted therapy of cardiovascular diseases, liver cancer and other illnesses while still a beginning in basic study and clinical disease treatment of ophthalmology. This review summarizes the current research of ultrasound microbubble contrast agent with drug and gene targeting therapy in basic study and clinical treatment of ophthalmology.