AIM: To evaluate the curative effect of esculin and digitalisglycosides eye drops on adolescent refractive asthenopia.

METHODS: Objects of study were patients with refractive asthenopia during April 2011 to April 2012, age from 6 to 18, totally 200 patients 400 eyes with typical visual fatigue symptoms were included. The enrolled patients used esculin and digitalisglycosides eye drops made by Germany, 1 drop per time,t.i.d. duration of the treatment lasted for 1 month. The improvement of treatment including visual fatigue, vision, dioptric change and drug adverse reactions were determined by conducting questionnaires rating.

RESULTS: Visual fatigue grade increased from 3.67 to 1.89 after the treatment, which had statistical significance(P<0.05). The naked eyesight of the patients improved from 4.43±0.38 to 4.60±0.49. Comparison differences between groups had statistical significance(t=-3.87, P<0.05). Dioptry decreased from -2.54±3.00D to -2.25±2.98D, but the differences had no statistical significance. There's no report for adverse reactions.

CONCLUSION:Esculin and digitalisglycosides eye drops is safe and effective in treating adolescent refractive asthenopia.