AIM: To study the clinical outcome of domestic natamycin medication for the treatment of fungal corneal ulcer comparing with imported natamycin.

METHODS: Twenty eyes of 20 patients from two eye hospitals who were diagnosed as fungal corneal ulcer participated in a randomized, controlled and blinded trial(September, 2010, through March, 2011). Twelve eyes were treated with domestic natamycin eye drops(treatment group), whereas other eight eyes were treated with imported natamycin eye drops(control group). Both groups received eye drops combined with anti-fungal systematic medication at the same dosage, once 0.5 hour for 12 days, once 1 hour for 2 days, once 2 hours for 5 days and once 3 hours for 2 weeks. The clinical efficacy was evaluated between two groups after 3, 5 and 7 days of treatment. Fisher precise test was statistically analyzed for differences.

RESULTS: The clinical effective rate in treatment group was 58.3%, which showed no significant difference with the 75% rate in control group(P>0.05).

CONCLUSION: Domestic natamycin eye drops is effective in the treatment of fungal corneal ulcer.