AIM: To dynamically observe the subtle structure changes in the acute central serous chorioretinopathy(ACSC)by optical coherence tomography(OCT).Compare the efficacy of laser, drug and the combined treatment.

METHODS: Totally 96 cases(98 eyes)of ACSC were confirmed by FFA and OCT, the differences of subretinal fluid absorption and visual acuity by drug, laser and laser combined with drug therapy were compared. Follow-up time was 2 weeks, 4 weeks and 8 weeks.

RESULTS: Between the groups were no statistically significant in the range of retinal detachment before treatment. After 2, 4 and 8 weeks treatment, the range of retinal detachment and cure rates were not statistically significant between the laser group and drug group. Compared to aforementioned two groups, a smaller range of retinal detachment and higher cure rate was found in combined treatment group, the differences were statistically significant.

CONCLUSION: The combined treatment of drug and laser can shorten the course of ACSC, improve the cure rate; OCT is noninvasive, simple, intuitive, can sensitively track the healing process of ACSC.