AIM:To observe the therapeutic effect of compound anisodine superficial temporal artery subcutaneous injection combined with acupuncture in treatment of blepharospasm.

METHODS: Totally 55 cases(67 eyes)blepharospasm patients with 30 cases in the experimental groups, 25 cases in the control group, the experimental groups were injected the compound anisodine hydrobromide injection 2mL in superficial temporal artery, and the control groups used simple acupuncture treatment.

RESULTS: After 14 days of treatment, among the experimental groups, 22 cases were of complete remission, 2 cases obvious remission, 5 cases partial remission, 1 case was ineffective; Among the experimental group, 11 cases were of complete remission, 2 cases obvious remission, 7 cases partial remission, 5 cases were ineffective, there were statistical significance 5 between the two groups(Z =-3.516, P=0.000<0.001), the therapeutic effect of the experimental groups were significantly superior to conventional control groups.

CONCLUSION: Compound anisodine superficial temporal artery subcutaneous injection combined with acupuncture treatment was effective, which could be the preferred treatment approach of blepharospasm and hemifacial spasm.