AIM:To study the therapeutic effect and safety of local injection of Bleomycin A5 for the treatment of eyelid xanthelasma.

METHODS:Bleomycin A5(0.8g/L)was injected directly into the mass of xanthelasma, 1/10d; 135 patients 256 eyes were enrolled in the study and the therapeutic effect was observed.

RESULTS:All the patients were followed up for 3-24 months, 8 eyes were cured by two injections, 32 eyes were cured by three injections, 198 eyes were cured by four injections, 18 eyes were cured by four more injections. No infection, no skin of eyelid necrosis and scar formation were found.

CONCLUSION:Local injection of light concentration Bleomycin A5 for xanthelasma is effective and safe.