AIM: To explore the curative effect of chymotrypsin in treating contusive hyphema at grade Ⅲ.

METHODS: Totally 84 patients(84 eyes)with contusive hyphema at grade Ⅲ were analyzed retrospectively. They were randomly divided into treatment group(42 cases)and control group(42 cases). The chymotrypsin was administrated in addition to routine treatment for treatment group, while the control group adoptedroutine treatment. Observation was made regarding the hyphema absorption time, visual recovery and complications.

RESULTS: The hyphema were absorbed after treatment in both groups, and visual acuity were improved at different levels in most patients. There were no significant differences in visual acuity after treatment in both two groups(P>0.05). The hyphema absorption time of the treatment group(7.45±0.35)d was significantly shorter than that of the control group(10.24±0.56)d. There was significant difference in the absorption time between the two groups(P<0.01). The complications occurrence was muchlower in the treatment group than that in the control group.

CONCLUSION: The hematocele of contusive hyphema patients at grade Ⅲ can be absorbed quickly through the chymotrypsin treatment, with less adverse reactions and complications.