AIM: To observe and compare the clinical effect and postoperative recrudescence rate and complication of pterygium surgery combined with bevacizumab or mitomycin C.

METHODS: Eighty pterygium inpatients in the Department of Ophthalmology in Integrated Chinese and Western Medicine Hospital of Zhejiang Province from January 2010 to January 2012 were randomly divided into two groups. Forty cases in group A were treated by surgery combined with subconjunctival injection of bevacizumab, Forty cases in group B were treated by surgery combined with mitomycin C sticking therapy. After following up for 1 year, the curative effect and postoperative recurrence rate and complications were compared and evaluated between the two groups.

RESULTS: The cure rate of group A and B were 88%, 85%, respectively, demonstrating no significant difference(χ²=0.105, P>0.05); The postoperative recurrence rate of group A, B were 12%, 15%, respectively, the differences of which weren't significantly different(χ²=0.105, P>0.05); The incidence of postoperative complications in group A, B were 2%, 18%, the differences of which weren't significantly different(χ²=4.517, P<0.05).

CONCLUSION: The clinical effect of pterygium surgery combined with bevacizumab or mitomycin C is significant with a low postoperative recrudescence rate, but the former has fewer complications.