AIM: To investigate the alterations of optic radiations(ORs)in monocular amblyopic children underwent treatment by using diffusion tensor imaging(DTI),and to explore its underlying neuromechanism.

METHODS: Eighteen children with anisometropic amblyopia(all left eyes)were recruited for amblyopia therapy. DTI data of ORs were acquired for each patient twice: before and after 9mo amblyopia therapy. The fractional anisotropy(FA)values and apparent diffusion coefficient(ADC)values were campared between the previous and posterior scans.

RESULTS: On both sides of ORs, the FA values of posterior therapy were higher than those of previous therapy(P<0.05), while the ADC values of posterior therapy were lower than those of previous therapy(P<0.05). The alterations of FA values and ADC values of ORs on the right side were greater than those of ORs on the left side after therapy(P<0.05).

CONCLUSION: Both sides of ORs in monocular amblyopic children are modified to varying degrees after myopia therapy.