AIM:To study expression of Bcl-2 and Bax in conjunctival tissue samples of conjunctivochalasis patients.

METHODS: To observe the histopathological change of conjunctivochalasis by HE staining of conjunctival tissue. Immunohistochemical staining was applied to compare the expression situation of Bcl-2 and Bax in conjunctival tissue of conjunctivochalasis patient(20 samples)and the normal conjunctiva tissue(10 samples).

RESULTS: There were lymphocyte and plasmocyte infiltration in the conjunctivochalasis tissue. The expression of Bcl-2 in the conjunctivochalasis was similar with the normal conjunctiva tissue(P>0.05). The expression of Bax in the two tissues showed significant difference(P<0.05). Spearman rank correlation analysis(r=0.432, P>0.05)indicated that there was no correlation between the expression of Bcl-2 and Bax.

CONCLUSION: Unbalanced expression of Bcl-2 and Bax in conjunctival tissue may play a significant role in the occurrence and development of conjunctivochalasis.