AIM: To explore the effects of oral acyclovir combined with sodium hyaluronate and fluorometholone eye drops on the treatment of herpes zoster keratitis.

METHODS:Forty patients with ocular herpes zoster were divided into two groups, 20 cases in the observation group, 20 cases in the control group. Observation group was treated with 200mg oral acyclovir for 5 times a day and sodium hyaluronate eye drops for 4 times a day. When stromal keratitis, disciform keratitis or corneal endotheliitis occurred, fluorometholone was used for 4 times a day. The control group was treated with ganciclovir ophthalmic gel for 4 times a day. The efficacy of two groups was observed, patients were followed up for 3-4wk.

RESULTS:The observation group of local pain and photophobia in remission time and corneal damage healing time were better than control group, and there were significant differences(P<0.05). There was efficient comparison, but no statistically significant difference.

CONCLUSION: Effects of oral acyclovir combined with sodium hyaluronate and fluorometholone eye drops on the treatment of herpes zoster keratitis are satisfactory.